Primarily used for blood irradiation, the Gammacell® 1000 and 3000 are considered the "gold standard" in countless clinics throughout the world. Both machines have a highly developed user interface with various input devices including keyboards and bar code scanners. Both machines have been refined with the valuable input of clinicians over many years and the result is a very user friendly control system. Each machine has numerous safety measures incorporated into the operating system to maintain accuracy and reliability.
Graft-Versus-Host Disease (GVHD)
Transfusion-Associated GVHD has become a major concern in current transfusion practices for immuno- deficient and immuno-suppressed patients because of the associated high mortality rate. Immuno-suppressive therapies have not proven effective for TA-GVHD. Virtually all cellular blood components have been implicated in reported cases of the disease. The syndrome develops after transfusion of whole blood, red blood cells, platelets, non-frozen plasma and leukocytes, harvested from both normal donors and donors with chronic myelocytic leukemia.
Since patient treatment of TA-GVHD is almost always ineffective, management must focus on prevention by minimizing the risk of developing the condition. Prevention has centered on reducing or inactivating transfused donor lymphocytes. The methods presently available in blood banks to physically remove T lymphocytes through washing or filtration do not provide effective prophylaxis against TA-GVHD. Inactivation of transfused lymphocytes with the use of gamma irradiation of blood components remains the most effective method for inhibiting lymphocyte blast transformation and mototic activity. Current medical practice and the AABB recommend using irradiated blood for immuno-incompetent or immuno-compromised patients.